Polyamine Profiles in Rat Testis, Germ Cells and Sertoli Cells During Testicular Maturation
نویسندگان
چکیده
منابع مشابه
DHT Germ cells Genital crest Testis Leydig Sertoli
Sex differentiation is a process that starts early during embryogenesis. In males, the SRY gene, located in the short arm of chromosome Y, encodes for the testis-determining factor, which causes the gonad to differentiate into testis. Testicular androgen synthesis by Leydig cells starts from the eighth week of development. It is initially stimulated by placental chorionic gonadotropin (HCG), an...
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Several in vivo studies have reported the presence of immunoreactive transforming growth factor-beta's (TGF-beta's) in testicular cells at defined stages of their differentiation. The most pronounced changes in TGF-beta1 and TGF-beta2 immunoreactivity occurred during spermatogenesis. In the present study we have investigated whether germ cells and Sertoli cells are able to secrete bioactive TGF...
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Objective(s): Sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. The present study was designed to analyze the effect of Sertoli cells in differentiation of mouse embryonic stem cells (mESCs) to germ cells. Materials and Methods: A fusion construct composed of a Stra8 gene promoter and the coding region of enhanced green fluorescence p...
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Objective(s): Although many researchers have confirmed induction of germ cells from bone marrow mesenchymal stem cells (BMMSCs), there are no reports that confirm spontaneous differentiation of germ cells from BMMSCs. In this study, we have evaluated the effect of adult Sertoli cell condition medium (SCCM) as a mutative factor in the induction of germ cells from BMMSCs. Materials and Methods: ...
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Background: Increases in the survival rate of men treated with chemotherapeutic drugs and their desire to have children precipitate concerns about the effects of these drugs on germ cells. This study performed to evaluation of protective effects of crocin in oxidative stress induced by cyclophosphamide (CP) on testis. Materials and Methods: Three groups (6 mice in each) of adult mice were used....
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ژورنال
عنوان ژورنال: Journal of Andrology
سال: 1989
ISSN: 0196-3635
DOI: 10.1002/j.1939-4640.1989.tb00076.x